Therapeutic Immunomodulation with Mesenchymal Stromal Cells: The Need for In Vivo Clues
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Keywords

Mesenchymal stem/stromal cell, immunomodulation, immuno- suppression, tolerance, scaffold, regenerative medicine

How to Cite

Dolcetti, L., & Dazzi, F. (2015). Therapeutic Immunomodulation with Mesenchymal Stromal Cells: The Need for In Vivo Clues. International Journal of Translational Science, 2015, 23–40. https://doi.org/10.13052/ijts2246-8765.2015.003

Abstract

Mesenchymal stem/stromal cells are effective therapeutic agents for a variety
of pathological conditions. However, the molecular mechanisms underlying
their action remain largely unknown and biased by in vitro studies. In this
concise review we have described recent advances in MSC therapeutics based
on in vivo observations. We have also discussed the possibility of using
engineering approaches to improve and facilitate deciphering MSC functions

https://doi.org/10.13052/ijts2246-8765.2015.003
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