Dexamethasone Induced Modulation of Reproduction: Investigating Role of Dexras1 Monomeric G Protein
Keywords:Reproduction, Dexamethasone, Dexras1, Reproduction, Stress, LH, FSH, Glucocorticoids.
Many factors like hormonal, anatomical, genetic, and environmental etc effect reproduction. Stressful conditions
like emotional-stress, altered level of hormones etc can cause alterations in release of reproductive hormones
thus ultimately effecting reproduction. In our study, we have focused to know the modulation of reproduction
induced by Dexamethasone (DEX) (a synthetic glucocorticoid), which mimics as a stress condition in female
mice and investigated the role of Dexras1 in reproduction under the influence of Dexamethasone.
Glucocorticoid are known to influence the release of GnRH hormone which in turn regulate the release of
reproductive hormones (LH, FSH). Dexamethasone is reported to upregulates Dexras1 expression. So we have
investigated the modulation of reproduction by alteration in the release of reproductive hormones LH and FSH
under DEX dosage in female mice. We observed that the level of hormones LH and FSH altered, in the
presence of Dexamethasone doses (0.1 and 0.5mg/kg mice). LH level is decreased while the level of FSH
increased with DEX dose. So the present study reveals the role of Dexamethasone in modulation of
reproduction. It has been reported earlier that Dexras1 is upregulated by Dexamethasone so we could suggest
that Dexras1 might involve in modulation of reproduction and could become a very important therapeutic target
in reproduction signaling processes.
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Group 1 Control Group 2 (0.1mg/kg) Group 3 (0.5mg/kg)
Journal of Graphic Era University
Vol. 8, Issue 1, 27-32, 2020
ISSN: 0975-1416 (Print), 2456-4281 (Online)
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