Electrospinning of Core-Shell Fibers for Drug Release Systems
DOI:
https://doi.org/10.13052/jsame2245-4551.2017.002Keywords:
Electrospinning, core-shell fibers, drug release, burst release, poly--caprolactone, poly-lactic acid.Abstract
Electrospinning is a promising method for the fabrication of fibers used
for drug release system, due the ease of operation of the electrospinning
process and the high surface to volume ratio, high loading capacity and
high encapsulation efficiency of the obtained fibers. In this study release
of tetracycline hydrochloride (TCH) from both monolithic and core-shell
electrospun fibers of poly-lactic acid (PLA), poly--caprolactone (PCL) and
their blend were studied. It was found that the drug release from the fibers
depended on their composition. Core-shell fibers were designed with PCL
and TCH in the core and with blends (PCL/PLA) of varying composition in
the shell. A varying initial burst release was observed when the composition
of the shell was varied. This illustrates that the burst release might be tunable
which can be advantageous for many applications
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