An Investigation of the Interaction between Melittin and a Model Lipid Bilayer
DOI:
https://doi.org/10.13052/jsame2245-4551.214Keywords:
Antimicrobial peptides, melittin, molecular dynamic simulations, self-assembled melittin/lipid bilayer poreAbstract
The recent emergence of multi-drug resistant bacteria has rendered many
common antibiotics ineffective and therefor novel drugs are needed. Antimi-
crobial peptides have proven applicable in this aspect as they can form
self-assembled pore structures in the lipid bilayer of bacterial cells. The
exact pore formation is shrouded in controversy and largely unknown as it is
difficult to determine empirically. The development of coarse grain force fields
in molecular dynamic simulations enables longer timescales and extended
simulation systems. This allows for the simulation of lipid bilayer self-
assembly and bilayer-antimicrobial peptide interactions. The present work
focuses on the antimicrobial peptide, melittin, induced pore formation and is
aimed towards determining the mechanism and pore structure
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