Molecular Combing of DNA: Methods and Applications
DOI:
https://doi.org/10.13052/same2245-4551.116Keywords:
Molecular combing of DNA, DNA stretching, AFMAbstract
First proposed in 1994, molecular combing of DNA is a technique that allows
adsorption and alignment of DNA on the surface with no need for prior modi-
fication of the molecule. Since then, many variations of the original method
have been devised and used in a wide range of applications from genomic
studies to nanoelectronics. While molecular combing has been applied in a
variety of DNA-related studies, no comprehensive review has been published
on different combing methods proposed so far. In this review, the underly-
ing mechanisms of molecular combing of DNA are described followed by
discussion of the main methods in molecular combing as well as its major
applications in nanotechnology.
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